Analyte quantification

Analyte quantification - context
Quantification of analyte
Quantification and standards
     External standard (ES) calibration
           advantage - disadvantage
                 Signal drift and ES calib.
                 Matrix effects and ES calib.
                 Analyte loss and ES calib.
     Internal standard (IS) calibration
           advantage - disadvantage
                 Signal drift and IS calib.
                 Matrix effects and IS calib.
                 Analyte loss and IS calib.
     Calibration by standard addition
Working range of the detector
Noise of the detector
Limit of detection and quantitation
Analyte recovery
Evaluation of an analytical method
Spike-recovery experiments using SS
End of lesson

Noise of the detector

Noise is the scatter of signal responses around the mean signal response of a sample containing no analyte (=blank), (which is given by the ordinate intercept of the calibration curve).

The noise is commonly described by the standard deviation of mean signal response, .