Analyte quantification
Analyte quantification - contextQuantification of analyte
Quantification and standards
External standard (ES) calibration advantage - disadvantage 
Signal drift and ES calib. 
Matrix effects and ES calib. Analyte loss and ES calib. Internal standard (IS) calibration advantage - disadvantage Signal drift and IS calib. Matrix effects and IS calib. Analyte loss and IS calib. 
Calibration by standard additionWorking range of the detectorNoise of the detectorLimit of detection and quantitationAnalyte recoveryEvaluation of an analytical methodSpike-recovery experiments using SS
End of lessonMatrix effects and ES calibration
matrix effect:
sample components suppress the response of the detector relative to 'clean' standards
example: signal suppression due to DOM (dissolved organic matter)
Signal suppression by matrix components in the sample results in quantified analyte concentrations in a sample that are systematically lower than the actual analyte concentrations in the sample.
