Analyte quantification
Analyte quantification - contextQuantification of analyte
Quantification and standards
External standard (ES) calibration advantage - disadvantage 
Signal drift and ES calib. 
Matrix effects and ES calib. Analyte loss and ES calib. Internal standard (IS) calibration advantage - disadvantage Signal drift and IS calib. Matrix effects and IS calib. Analyte loss and IS calib. 
Calibration by standard additionWorking range of the detectorNoise of the detectorLimit of detection and quantitationAnalyte recoveryEvaluation of an analytical methodSpike-recovery experiments using SS
End of lessonSignal drift and ES calibration
signal drift*:
temporal changes in the response of the detector to a constant analyte concentration
signal drift equally affects standards and samples
example: increase in signal response to a given sample over time
Signal drift results in a systematic error because samples and external calibration standards are measured at different times.
* typically has electronic causes
