Qualitative understanding of partition preferences

Introduction
Cavity model
Rules for partitioning ...
     ...of a given compound
           Recall information ...
           Case Ia
           Case Ib
           Case Ic
           Case IIa
           Case IIb
           Other cases
           Overview
           Furter information
     ...of various compounds
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The cavity model in quantitative terms

Selftest
Problems
Intermolecular interactions in every day life
FAQ

Case Ic

 

Rule 1(c):
A bipolar solute will partition similarly (i.e. partition coefficients vary by less than a factor 3) to all apolar phases because only vdW interactions are involved in the cavity formation as well as in the interactions between solute and solvent.

 

compound
 / 
 solvent
Ksolvent / air
ethanol
/
 decane
38

bipolar molecules
in apolar phases:

only van-der Waals
Interactions

ethanol
/
 CCl4
115
ethanol
/
 cyclohexane
45
water
/
 heptane
4.47
water
/
 1,2,4-trichlorobenzene
12.5
water
/
 tetracloroethylene
6.67

 

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