Qualitative understanding of partition preferences

Introduction
Cavity model
Rules for partitioning ...
     ...of a given compound
           Recall information ...
           Case Ia
           Case Ib
           Case Ic
           Case IIa
           Case IIb
           Other cases
           Overview
           Furter information
     ...of various compounds
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           Page 5/5
The cavity model in quantitative terms

Selftest
Problems
Intermolecular interactions in every day life
FAQ

Case Ib

 

Rule 1(b):
A monopolar solute will partition similarly (i.e., partition coefficients vary by less than a factor 3) to all apolar phases and monopolar phases of the same polarity because only vdW interactions are involved in the cavity formation as well as in the interactions between solute and solvent. (The data shown below for partitioning into decane are exceptions from this rule.)

 


compound
 / 
solvent
Ksolvent / air

butanone
/
decane
254

monopolar molecules in
monopolar phases of the same
polarity and in apolar phases:

only van-der-Waals
interactions

butanone
/
cyclohexane
1301
butanone
/
butylether
533
butanone
/
benzylether
985
 
dioxane
/
decane
813
dioxane
/
CCl4
4326
dioxane
/
cyclohexane
1106
dioxane
/
toluene
4080
dioxane
/
diethyl ether
2436
dioxane
/
benzylether
3122

 

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