Qualitative understanding of partition preferences

Introduction
Cavity model
Rules for partitioning ...
     ...of a given compound
           Recall information ...
           Case Ia
           Case Ib
           Case Ic
           Case IIa
           Case IIb
           Other cases
           Overview
           Furter information
     ...of various compounds
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The cavity model in quantitative terms

Selftest
Problems
Intermolecular interactions in every day life
FAQ

Case Ia

 

Rule 1(a):
An apolar solute will partition similarly (i.e., partition coefficients vary by less than a factor 3) to all apolar and monopolar phases because only vdW interactions are involved in the cavity formation as well as in the interactions between solute and solvent. Empirically one finds that such partition coefficients typically vary by less than a factor 3.

 

Solvent/air partitioning of octane:


solvent
Ksolvent / air

decane
6688

apolar molecules in
apolar or monopolar phases:

only van-der Waals
Interactions

CCl4
11142
cyclohexane
11227
toluene
7387
ethyl ether
8287

 

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