Sample preparation
Sample preparation - context
Sample preparation - motivation
Purpose of sample preparation
Interferents in the sample ...
LOD and LOQ
Overview of preparation methods
Liquid liquid extraction (LLE)
Solid phase extraction (SPE)
Solid phase microextraction (SPME)
Purge and trap (PT)
(Accelerated) Solvent extraction ((A)SE)
Supercritical fluid extraction (SFE)
Filter Techniques (FT)
Box 10 Filtration
Box 11 Sorbents
Box 12 Preconcentration
Self test
Problems
End of chapter
Purpose of sample preparation
1. Cleaning
complex sample matrix contains:
analyte(s)
and
interferents
(e.g, natural organic matter, salts, ...)
2. Analyte pre-concentration
samples often have an
analyte concentration
C
analyte
below detection limit
1. and 2. are often both achieved by a single preparation method