Sample preparation

Sample preparation - context
Sample preparation - motivation
Purpose of sample preparation
     Interferents in the sample ...
     LOD and LOQ
Overview of preparation methods
     Liquid liquid extraction (LLE)
     Solid phase extraction (SPE)
     Solid phase microextraction (SPME)
     Purge and trap (PT)
     (Accelerated) Solvent extraction ((A)SE)
     Supercritical fluid extraction (SFE)
      Filter Techniques (FT)
Box 10 Filtration
Box 11 Sorbents
Box 12 Preconcentration
Self test
Problems
End of chapter


Purpose of sample preparation


1. Cleaning

complex sample matrix contains:

 

 

 

analyte(s)
and interferents
(e.g, natural organic matter, salts, ...)

 

 

2. Analyte pre-concentration

 

samples often have an

analyte concentration Canalyte

below detection limit

1. and 2. are often both achieved by a single preparation method